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标题：Dose-response Relationship for Lifetime Excess Mortality and Temporal Pattern of Manifestation in Mice Irradiated Neonatally with Gamma Rays
其他标题：Dose-response Relationship for Lifetime Excess Mortality and Temporal Pattern of Manifestation in Mice Irradiated Neonatally with Gamma Rays
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作者：SHUNSAKU SASAKI ; NOBUO FUKUDA
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2002
卷号：43
期号：3
页码：313-323
DOI：10.1269/jrr.43.313
摘要：The dose-response relationships for the lifetime excess mortality and temporal distribution of excess mortality were analysed using a data set from an experiment on the long-term effects of gamma irradiation in neonatal mice. The excess mortality was calculated based on an assumption that any increase in the mortality rate was attributable to radiation exposure. The dose-response relationship for the lifetime excess mortality was convex upward, whereas the shortening of the mean life span was proportional to the dose. The excess mortality at 1 Gy was estimated to be 35.6%. The relative risk decreased markedly with increasing age. However, the mortality rate in the irradiated group was persistently higher than the background rate of death, and the absolute risk increased with age. A logistic specification was used to analyze the temporal distribution of the excess mortality. The results of the analysis indicated a dose-dependent shortening of the latent period and a broadening of the distribution.
关键词：Lifetime risk; Excess mortality; Dose-response; Neonatal mice; Gamma rays