文章基本信息

标题：Changes in Histological Construction and Decrease in 3H-QNB Binding in the Rat Brain after Prenatal X-irradiation
其他标题：Changes in Histological Construction and Decrease in 3H-QNB Binding in the Rat Brain after Prenatal X-irradiation
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作者：SOTARO MOMOSAKI ; XUE-ZHI SUN ; NOBUHIKO TAKAI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2002
卷号：43
期号：3
页码：277-282
DOI：10.1269/jrr.43.277
摘要：To elucidate the mechanisms involved in deleterious neuronal and behavioral changes after prenatal ionizing irradiation, in vitro muscarinic acetylcholine (mACh) receptor binding and histological construction were investigated in 9-week old rat brains after 1.5 Gy X-ray exposure on embryonic day 15 (E15). A gross anatomical examination with a magnetic-resonance imaging system showed an irregular tissue construction in the hippocampus and cortex of the irradiated rat brain. Histological sections stained with hematoxylin and eosin also indicated that the structures of the hippocampus and cortex were obviously changed. In irradiated rats, the laminar structure of pyramidal cells was selectively deranged in the CA1 region. In vitro 3 H-Quinuclidinyl benzilate binding in the hippocampus was significantly decreased (about 10%) in prenatal irradiated rats compared to that in sham-treated rats. On the other hand, no significant change in mACh receptor binding was observed in the cerebral cortex. The present study revealed that prenatal exposure to ionizing radiation may induce dysfunction of the cholinergic neuronal systems, especially in the hippocampus, resulting in deleterious changes in memory and behavior.
关键词：X-irradiation; Hippocampus; Histological change; MRI; Muscarinic acetylcholine receptor binding