文章基本信息

标题：Radioprotective Effects of 2-Iminothiazolidine Derivatives against Lethal Doses of Gamma Radiation in Mice
其他标题：Radioprotective Effects of 2-Iminothiazolidine Derivatives against Lethal Doses of Gamma Radiation in Mice
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作者：SEYED JALAL HOSSEINIMEHR ; ABBAS SHAFIEE ; HOSSEIN MOZDARANI 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：2001
卷号：42
期号：4
页码：401-401
DOI：10.1269/jrr.42.401
摘要：Although thiol-containing compounds have long been known to possess radioprotective properties, their therapeutics utility is limited by their side effects at radioprotective doses. In this study, a series of 2-iminothiazolidine derivatives were prepared and their toxicity and radioprotective effects in NMRI mice were determined using the LD 50/30 end point. The LD 50 values, as determined by a Probit analysis, were between 11 and 14 mg/kg. For studying radioprotective effects, one-sixth of the toxic LD 50 values were used, namely 2 and 2.2 mg/kg. To evaluate the radioprotective capabilities, mice were exposed to lethal doses of cobalt-60 γ-radiation alone or in the presence of compounds. The percentage survival of mice at 30 days for these compounds compared to control mice were 10 to 30% when injected 15 and 30 minutes before γ-irradiation. They were significant compared to the control group (P0.05).
关键词：Radioprotectors;2-iminothiazolidine;LD50;γ-radiation;Mice