文章基本信息

标题：Effect of Ionizing Radiation on the Differentiation of ROS 17/2.8 Osteoblasts through Free Radicals
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作者：HAN-JUNG CHAE ; SOO-WAN CHAE ; JANG-SOOK KANG 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1999
卷号：40
期号：4
页码：323-335
DOI：10.1269/jrr.40.323
摘要：Although the acceleration of bone regeneration by radiation has been reported, the mechanisms of action of radiation on bone are unclear. The present results indicate that ionizing radiation-stimulated differentiation could result from the generation of reactive oxygen species during radiation exposure. The free radical release is considered as the most important mechanism of bone effect by radiation treatment. In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. The JNK and AP-1 activation is mediated with radiation-released free radicals in ROS 17/2.8 osteoblasts. These results indicate that ionizing radiation at a single dose of up to 5 Gray stimulates differentiation of ROS 17/2.8 osteoblasts via free radial release which may affect JNK/SAPK and AP-1 activities.
关键词：Ionizing radiation;ROS 17/2.8 osteoblasts;Alkaline phosphatase;JNK-SAPK;AP-1