文章基本信息

标题：Recovery from Ultraviolet Light-Induced Depression of Ribosomal RNA Synthesis in Normal Human, Xeroderma Pigmentosum and Cockayne Syndrome Cells.
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作者：HITOSHI AYAKI ; RYUJIRO HARA ; MITUO IKENAGA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1996
卷号：37
期号：2
页码：107-116
DOI：10.1269/jrr.37.107
摘要：The rate of ribosomal RNA (rRNA) synthesis was analyzed at different times after ultraviolet light (UV) irradiation in normal human, xeroderma pigmentosum (XP) and Cockayne syndrome (CS) cells. In normal cells, the rate of rRNA synthesis, as measured by the incorporation of 3 H-uridine into 18S and 28S rRNAs, decreased immediately after UV irradiation to about half of that of unirradiated cells, and then recovered significantly at 24 h after UV. However, the rate of synthesis continued to decrease during post-UV incubation in XP cells belonging to groups A, D, E, F and G, as well as in CS cells of groups A and B. In contrast, group C XP cells showed a slight recovery at 24 h after UV, suggesting that they have the capacity to repair UV lesions in rRNA genes.
关键词：Recovery of ribosomal RNA synthesis; UV-irradiation; Xeroderma pigmentosum; Cockayne syndrome