文章基本信息

标题：Modification of Radiosensitivity by the So-called Tissue Recovery Stimulator. I. Radiosensitizing Effects of Solcoseryl.
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作者：ASHOK KUMAR ; HIROSHI KIMURA ; TAKASHI AOYAMA 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1992
卷号：33
期号：4
页码：282-289
DOI：10.1269/jrr.33.282
摘要：The effect of solcoseryl on the growth, radiosensitization and ability of V79 cells to recover from X-ray-induced damage has been observed. Solcoseryl at 0.8 mg/ml was the optimal concentration for the stimulation of cell growth. Increased sensitivity to X-irradiation was found in the shoulder region of V79 cells treated before and after irradiation with solcoseryl (0.8 mg/ml). The Dq and extrapolation number (n) decreased. Solcoseryl treatment apparently does not reduce split dose recovery or inhibit the repair of potentially lethal damage. Flow cytofluorometry studies of the cell cycle distribution and mitotic index show that solcoseryl inhibits the expression of radiation-induced cell arrest in the G 2 phase of the cell cycle. Although this action increases radiation sensitization, additional mechanisms probably exist.
关键词：Radiosensitization;Gowth stimulation;Cell cycle distribution;V79 cells