文章基本信息

标题：Biological assessment of the enhancement of tritium excretion by administration of diuretics and excessive water in mice.
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作者：NAOKI KUNUGITA ; SEITARO DOHI ; HISAO YAMAMOTO 等
期刊名称：Journal of Radiation Research
印刷版ISSN：0449-3060
电子版ISSN：1349-9157
出版年度：1990
卷号：31
期号：4
页码：361-374
DOI：10.1269/jrr.31.361
摘要：This study was undertaken to determine whether or not the administration of diuretics and excess water after tritium exposure would have any positive reducing effect not only on the retention of tritium but also on the radiation damage of hematopoietic tissue in mice. When mice were treated with diuretics and excess water for a few days after injection of tritiated water (HTO), radioactivity within the body fluid and tissues was reduced, and the number of CFU-s, clonability of splenic T cells and proliferative activity assayed by Con-A blastogenesis were increased in comparison with those in the controls. When the mice were injected with a large dose of HTO (811 MBq/mouse) to assay survival, no mice treated with diuretic and excess water died 80 days after injection, while 80% of the controls died during the first month. The final committed dose in the mice treated early with diuretics was calculated to be 60% of that in the controls. These results suggest that treatment with diuretics and excess water is useful for practical purposes when a human is accidentally exposed to tritium.
关键词：Tritiated water; Tritium excretion; Diuretic; Cumulative dose; Mice