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标题：Prenatal and childhood exposure to phthalic acid esters and vaccination antibodies in children: A 15-year follow-up birth cohort study
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作者：Hui-Ju Wen ; Yue Leon Guo ; Pen-Hua Su 等
期刊名称：Environment International
印刷版ISSN：0160-4120
电子版ISSN：1873-6750
出版年度：2020
卷号：145
页码：1-8
DOI：10.1016/j.envint.2020.106134
出版社：Pergamon
摘要：Phthalic acid esters (PAE) are widely used during chemical synthesis and do not form covalent linkages with products. It has been reported that exposure to PAE affects the immune response. However, their effect on antibody concentrations in children is still under investigation. We aimed to examine the association between early-life phthalate exposure and antibody concentrations in children in a longitudinal birth cohort established in 2000–2001. We recruited 398 neonates in central Taiwan and followed them up every 2–3 years, with various antibody-related studies at 11- and 14-year follow-ups. Seven urinary phthalate metabolites were quantified in mothers during pregnancy and children aged 11 years. Four antibody concentrations were analyzed in children aged 11 and 14 years. The percent change in antibody concentrations from ages 11 to 14 years was calculated and its association with phthalate exposure was evaluated via multivariate regression analysis. Eighty-one followed-up children were with sufficient data. After adjusting for prenatal exposure and other confounders, double concentrations of the urinary sum of di-2-ethylhexyl phthalate (ΣDEHPm) and mono-n-butyl phthalate (MnBP) were associated with a 18.06% (95% CI = 3.34%, 32.78%) and 22.53% decrease (95% CI = 3.39%, 41.66%) in antibody concentration against hepatitis B, respectively. Phthalate exposure was found to be related to decreased antibody concentrations against hepatitis B (DEHP, DBnP) in the early teens. This exposure is suggested to be considered for clinical re-booster vaccines among junior high school students. Further verification with additional cohorts and studies on the underlying mechanisms of phthalate exposure are warranted.
关键词：Birth cohort ; Phthalate ; Children ; Antibody ; Vaccine ; Hepatitis B ; AM arithmetic mean ; AntiHBs antibody against hepatitis B ; BBzP benzyl butyl phthalate ; CI confidence interval ; DAG DAGitty ; DEP diethyl phthalate ; DEHP di-2-ethylhexyl phthalate ; DMP dimethyl phthalate ; DnBP Di-n-butyl phthalate ; EDC endocrine-disrupting chemicals ; GM geometrical mean ; HBV hepatitis B virus ; INF interferon ; IQR interquartile range ; LD limit of detection ; MEP mono-ethyl phthalate ; MMP mono-methyl phthalate ; MnBP mono-n-butyl phthalate ; MBzP mono-benzyl phthalate ; MEHP mono-2-ethylhexyl phthalate ; MEHHP mono-2-ethyl-5-hydroxyhexyl phthalate ; MEOHP mono-2-ethyl-5-oxohexyl phthalate ; PAE phthalic acid esters ; pDCs plasmacytoid dendritic cells ; PFOA Perfluorooctanoic acid ; PFOS perfluorooctane sulfonic acid ; SD standard deviation