文章基本信息

标题：Effect of fish oil and telmisartan on dehydroepiandrosterone‐induced polycystic ovarian syndrome in rats: The role of oxidative stress, transforming growth factor beta‐1, and nuclear factor kappa B
本地全文：下载
作者：Ahmed M. Kabel ; Ahmed M. Ashour ; Mohamed S. Omar 等
期刊名称：Food Science & Nutrition
电子版ISSN：2048-7177
出版年度：2020
卷号：8
期号：9
页码：1-11
DOI：10.1002/fsn3.1819
出版社：John Wiley & Sons, Ltd.
摘要：Our aim was to explore the effect of telmisartan and/or fish oil on dehydroepiandrosterone (DHEA)‐induced PCOS in rats. Sixty female rats were divided into six equal groups as follows: Control; DHEA‐induced PCOS; DHEA Telmisartan; DHEA Fish oil; DHEA Carboxymethyl cellulose; and DHEA Telmisartan Fish oil group. Plasma sex hormones, anthropometric measurements, and the glycemic indices were measured. Tissue oxidative stress parameters and the proinflammatory cytokines were assessed. The ovaries were subjected to histopathological and electron microscopic examination. Telmisartan and/or fish oil induced significant improvement of insulin resistance with amelioration of oxidative stress and inflammation compared to PCOS group. Also, telmisartan and/or fish oil restored the hormonal levels and the anthropometric measurements to the normal values. This was significant with telmisartan/fish oil combination compared to the use of each of these agents alone. In conclusion, this combination may represent a promising hope for amelioration of PCOS.
关键词：fish oil;nuclear factor kappa B;polycystic ovarian syndrome;rats;telmisartan;transforming growth factor beta‐1