文章基本信息

标题：Activation of Ligand Reaction on an Iron Complex: H/D Exchange Reaction of a Low-Spin Bis[2-(Pyridylmethylidene)-1-(2-pyridyl)methylamine]iron(II) Complex
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作者：Masanori Imai ; Koichi Kato ; Yoshihiro Yamaguchi 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：8
页码：713-716
DOI：10.1248/cpb.c20-00383
出版社：The Pharmaceutical Society of Japan
摘要：With the aim of shedding some light on the still scarcely investigated mechanism of transformation of imines in metal complexes, this study describes the investigation of the hydrogen–deuterium (H/D) exchange reaction of a bis[2-(pyridylmethylidene)-1-(2-pyridylmethylamine]iron(II) complex ([Fe(PMAP)2 ] 2+ ), following our previous work on a low-spin iron(II) complex bearing two molecules of S -2-pyridylmethylidene-1-(2-pyridyl)ethylamine. This complex has been proven to undergo successive transiminations in acetonitrile, yielding a bis[1-(2-pyridyl)ethylidene-2-pyridylmethylamine]iron(II) complex. In the analogous [Fe(PMAP)2 ] 2+ complex, a 1,3-hydrogen rearrangement occurs in a 10% deuterium oxide-acetonitrile- d 3 (D2 O–CD3 CN) solution. The H/D exchange reaction of [Fe(PMAP)2 ] 2+ was examined in the presence of various concentrations of 2,6-dimethylpyridine as a base in a 10% D2 O–CD3 CN solution at 45 ° C, and the reaction mechanism was investigated.
关键词：hydrogen–deuterium exchange reaction;iron complex;2,6-dimethylpyridine;acetonitrile-d3;deuterium oxide