文章基本信息

标题：Comparative Study of the Protective Effect of Cola anomala and Coffea arabica Against Induced Toxicity in Rats
本地全文：下载
作者：M-A. Angie Mbong ; F. L. Ebouel Edoun ; L. C. Manga Ngandi 等
期刊名称：Journal of Food Research
印刷版ISSN：1927-0887
电子版ISSN：1927-0895
出版年度：2020
卷号：9
期号：5
页码：1-13
DOI：10.5539/jfr.v9n5p1
出版社：Canadian Center of Science and Education
摘要：This work was aimed at evaluating the effects of C. anomala and C. arabica on Methotrexate (MTX) induced metabolic disorders. For this, the aqueous extract (AE) of C. anomala and C. arabica were prepared and their polyphenols, flavonoids and alkaloids contents determined as well as their antiradical and total antioxidant capacity. An animal experimentation using female rats was carried out for 14 days. Rats were divided into 6 groups; a negative control group receiving water; a positive control group receiving 12mg/Kg Bw of MTX; four tests groups receiving 12mg/Kg Bw of MTX and one of the extracts at a dose of 200mg/Kg Bw or 400mg/Kg Bw. At the end of the experiment, plasmas and hemolysates were prepared as well as liver and kidney homogenates for the evaluation of oxidative status (catalase, total protein and malondialdehyde (MDA)), liver toxicity (alanine amino transferase (ALT)) and renal toxicity (creatinine and urea) and lipid profile (triglycerides, total cholesterol and HDL-cholesterol). Weight gain in extract-treated rats was better with the C. anomala . Concerning oxidative status, MDA levels were generally lower in C. anomala -treated groups compared to C. arabica while catalase level was higher in C. anomala -treated rats. As for lipid profile, it is C. arabica that showed more or less better results. Both extracts led to an amelioration of toxicity markers compared to exclusive treatment with MTX. The results of this study suggest that C. anomala and C. arabica may reduce metabolic disorders associated with the intake of MTX during cancer treatment; C. anomala protecting better C. arabica .
关键词：Cola anomala;Coffea Arabica;Methotrexate;metabolic disorders