文章基本信息

标题：Schizophrenia : Current concepts in aetiology
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作者：Col P S Bhat ; Surg Lt Cdr Puneet Khannab ; Lt Col K J Divinakumar 等
期刊名称：Journal of Marine Medical Society
印刷版ISSN：0975-3605
电子版ISSN：2589-1235
出版年度：2014
卷号：16
期号：1
页码：7-9
DOI：10.4103/0975-3605.203348
语种：English
出版社：Medknow Publications
摘要：Schizophrenia is perhaps the most devastating neuropsychiatric illness.Worldwide,its prevalence rate is about 1%.Schizophrenia is considered a neurodevelopmental disorder involving the interplay of susceptibility genes and environmental factors.There is a wide range of pathologic findings,but there is n0 specific or diagnostic laboratory abnormality.Till date,the aetiology,neuropathology,and pathophysiology of schizophrenia remain elusive.Over the last forty years,the dopaminergic model has been the leading neurochemical hypothesis of schizophrenia.Yet it remains unlikely that dopaminergic dysfunction,on its own.Glutamatergic models provide an alternate approach for conceptualizing the brain abnormalities associated with schizophrenia.New pharmacological and behavioral approaches aimed at potentiating glutamatergic neurorarnmission,offer new hope for future clinical development.
关键词：Schizophrenia;Glutamate;Dopamine