文章基本信息

标题：Neural stem cells and post traumatic epilepsy: The importance of seizure control
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作者：KI Mathai ; S Ranjan ; S Das 等
期刊名称：Journal of Marine Medical Society
印刷版ISSN：0975-3605
电子版ISSN：2589-1235
出版年度：2012
卷号：14
期号：1
页码：46-48
DOI：10.4103/0975-3605.203231
语种：English
出版社：Medknow Publications
摘要：Post traumatic seizures induce structural and neurochemical changes in the Neural Stem cell (NSC) niches.The NSC niche shows a classic biphasic response to seizures.In the early weeks after a post traumatic seizure,there is an increase in neurogenesis.However,the integration of these new neurons into existing circuitry is defective leading on to epileptogenic circuits.As seizures continue,there is a decrease in neural proliferation,with consequences on cognition and mood.In this article,we explore the aetiopathogenesis of hippocampal epileptic circuitry and discuss conceptual and evolv ing therapeutic options.
关键词：Post traumatic epilepsy;Neural stem cells.