摘要:Meningomyelocele is a neural tube defect,which comprises of a saccular protrusion containing a neural placode bathed in cerebral spinal fluid.Arachnoid covers the surface of the sac and dura or skin is missing.This is a congenital spinal anomaly,a type of spina bifida where there is a failure of fusion of spine.Early surgery is advisable because of increased risk of infection and further damage to nervous tissue.Anesthetic challenges for meningomyelocele surgical repair in a neonate include intubation with proper positioning to avoid rupture of sac,intraoperative prone position ventilation and its related complications maintenance of anesthesia,temperature control,and fluid management.We present a case report of anesthetic challenge of a 2-day-old neonate for detethering and repair of lumbosacral meningomyelocele.