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标题：Phenolic compounds of Iris adriatica and their antimycobacterial effects
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作者：SANDRA OCHENSBERGER ; FABIAN ALPERTH ; BOŽENA MITIĆ 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2019
卷号：69
期号：4
页码：673-681
DOI：10.2478/acph-2019-0037
语种：English
出版社：Sciendo
摘要：Little is known about the pharmacological activities of Iris adriatica (Iridaceae),a plant endemic to Dalmatia (Croatia).We therefore performed a bioassay-guided fractionation including highperformance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc² 155.One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L–1.Furthermore,fractions were tested for resistance modulatory effects using ethidium bromide as substrate.We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone,responsible for the resistance-modulatory activity of this plant.
关键词：Iris adriatica;Radix Iridis;phenolic compounds;Mycobacterium smegmatis;resistance modulation;ethidium bromide;MIC