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标题：A modern approach to the treatment of plaque psoriasis
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作者：DANIELA LEDIĆ DRVAR ; TOMISLAV VLAHINIĆ ; ŽELJAN MALEŠ 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2019
卷号：69
期号：4
页码：511-523
DOI：10.2478/acph-2019-0047
语种：English
出版社：Sciendo
摘要：Psoriasis is a common chronic inflammatory skin disease which affects 0.5–1 % of children and 2–3 % of the adult population.In Croatia,1.6 % of the population suffer from psoriasis.Distribution of the disease is bimodal,with the first peak at the age of 20–30,and the second at the age of 50–60.The etiopathogenesis of the disease is multifactorial,the key factors being genetic predisposition combined with immunological disorders,environmental factors and skin barrier damage.There are several clinical variants of the disease.The main signalling pathways in psoriasis include TNF-α,IL-23 and IL-17.Topical agents are used for the treatment of the mild form,and the systemic conventional therapy is used for the treatment of moderate to severe forms of the disease.In cases where’s no response,or intolerance or contraindications are present,new targeted medications are to be administered.Development in the field of immunogenetics of psoriasis leads to personalized medicine.
关键词：psoriasis;topical treatment;conventional systemic therapy;small molecules;biologicals