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标题：Secondary metabolites from the resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation
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作者：NAJEEB UR REHMAN ; SAMIA AHMED AL-RIYAMI ; HIDAYAT HUSSAIN 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2019
卷号：69
期号：3
页码：433-441
DOI：10.2478/acph-2019-0027
语种：English
出版社：Sciendo
摘要：Oxidative stress is often considered detrimental for cellular processes and damaging for the lipid bi-layer.Counteracting such stresses with the aid of nature-based chemical constituents can be an ideal therapeutic approach.The current study aimed to investigate the chemical constituents of resins derived from the well-known Aloe vera and less known Commiphora mukul trees and their effect in mitigating the lipid peroxidation (LPO) process.The bio-guided isolation of bioactive fractions from both resins afforded 20 chemical constituents (17 from A.vera and 3 from C.mukul).These compounds belonged to anthraquinones,anthraquinone glycosides,quinones,coumarins,polypodane-type terpenoids and benzene derivatives.Major chemical constituents of the resins of A.vera and C.mukul were from the classes of quinones and terpenoids.Feroxidin (4,from A.vera) showed slightly higher inhibition (IC50 = 201.7 ± 0.9 µmol L–1) than myrrhanone C (18,from C.mukul: IC50 = 210.7 ± 0.0 µmol L–1) and methyl 3-(4-hydroxyphenyl) propionate from A.vera (13,IC50 = 232.9 ± 0.2 µmol L–1) compared to the other compounds.Structure-activity relationship showed that the existence of hydroxyl,methoxy and ether groups might play a major role in countering oxidative stress.To the best of our knowledge,anti-LPO activities of compounds 1–4,14,18 and 20 are reported for the first time.Such chemical constituents with high anti-lipid peroxidation activity could be helpful in synthesizing candidate drugs.
关键词：Aloe vera;Commiphora mukul;anti-LPO;feroxidin;myrrhanone C