文章基本信息

标题：Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes
本地全文：下载
作者：DONG-GI LEE ; IK SOON JANG ; KYEONG EUN YANG 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2016
卷号：66
期号：2
页码：297-302
DOI：10.1515/acph-2016-0021
语种：English
出版社：Sciendo
摘要：This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model.The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis.Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly.Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B;it is negative regulator of insulin pathway,both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner.In conclusion,rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.
关键词：tartary buckwheat sprout;rutin;type 2 diabetes;insulin signaling