文章基本信息

标题：Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method
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作者：BOŻENA KAROLEWICZ ; KAROL NARTOWSKI ; KAROL NARTOWSKI 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2016
卷号：66
期号：1
页码：119-128
DOI：10.1515/acph-2016-0008
语种：English
出版社：Sciendo
摘要：The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at diff erent drug-to-polymer ratios.The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies,diff erential scanning calorimetry and powder X-ray diff raction analysis.The dissolution rate of acyclovir was determined using the rotating disk method.It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %.
关键词：acyclovir;Pluronic F127;solid dispersions;physical mixtures;kneading;dissolution improvement