文章基本信息

标题：In vitro antioxidant activity of stem bark of Trichilia catigua Adr.Juss
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作者：JEAN PAUL KAMDEM ; JEAN PAUL KAMDEM ; SÍLVIO TERRA STEFANELLO 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2012
卷号：62
期号：3
页码：371-382
DOI：10.2478/v10007-012-0026-x
语种：English
出版社：Sciendo
摘要：Antioxidant activity of the ethanolic extract and fractions from the stem bark of T.catigua was investigated.IC50 (for DPPH scavenging) by T.catigua varied from 9.17 ± 0.63 to 76.42 ± 5.87 mg mL–1 and total phenolic content varied from 345.63 ± 41.08 to 601.27 ± 42.59 mg GAE g–1 of dry extract.Fe2+-induced lipid peroxidation was significantly reduced by the ethanolic extract and fractions.Mitochondrial Ca2+-induced dichlorofluorescein oxidation was significantly reduced by the ethanolic extract in a concentration-dependent manner.Ethanolic extract reduced mitochondrial Dym only at high concentrations (40–100 mg mL–1),which indicates that its toxicity does not overlap with its antioxidant effects.Results suggest involvement of antioxidant activities of T.catigua in its pharmacological properties.
关键词：Trichilia catigua (Meliaceae);antioxidant;flavonoids;phenolics;reactive oxygen species;oxidative stress