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标题：Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochloride
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作者：BAZIGHA K. ABDUL RASOOL ; UDAY S. AZIZ ; OMAR SARHEED 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2011
卷号：61
期号：3
页码：271-282
DOI：10.2478/v10007-011-0025-3
语种：English
出版社：Sciendo
摘要：The objective of the study was to develop a suitable transdermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former.Drug concentration uniformity,thickness,moisture uptake capacity and skin bioadhesion of the films were characterized.The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated.Skin irritation of the candidate film was evaluated.Chitosan film (PPL 2 mg cm–2,chitosan 2 %,m/m,cineol 10 %,m/m) was found nonirritant and achieved 88.2 % release after 8 hours in phosphate buffer.Significant high (p < 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor),making it a promising transdermal delivery system for PPL.
关键词：transdermal delivery;propranolol hydrochloride;chitosan film;enhancers