文章基本信息

标题：Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives
本地全文：下载
作者：MOSAAD SAYED MOHAMED ; SAMIR MOHAMED AWAD ; NAGLAA MOHAMED AHMED 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2011
卷号：61
期号：2
页码：171-185
DOI：10.2478/v10007-011-0019-1
语种：English
出版社：Sciendo
摘要：A series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes.These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-d to 10a-d).All compounds were screened for antibacterial and antifungal activities.Some of the prepared compounds,6-(4-fluorophenyl)-4- -oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a),4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4- -tetrahydropyrimidine-5-carboxamide (2d),6-(4-fluorophenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-cabonitrile (7a) and 4-hydrazino-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2-dihydropyrimidine-5-carbonitrile (7d) revealed promising antimicrobial activity.
关键词：6-aryl-5-cyano-2-thiouracil;antibacterial activity;antifungal activity