文章基本信息

标题：Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene,hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities
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作者：RAFAT M. MOHAREB ; RAFAT M. MOHAREB ; HOSAM E. MOUSTAFA 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2011
卷号：61
期号：1
页码：51-62
DOI：10.2478/v10007-011-0001-y
语种：English
出版社：Sciendo
摘要：The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities.The title reagent reacted with cyclohexanone to give the ethylidene derivative 2.The reactivity of the latter product towards different chemical reagents was studied to give tetrahydronaphthalene,hexahydroisoquinoline and hexahydrocinnoline derivatives.The newly synthesized products were screened as antitumor agents on the in vitro growth of three human tumor cell lines representing different tumor types,namely,breast adenocarcinoma (MCF-7),non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268).It was found that some of these compounds showed inhibitory effects on the three cell lines,indicating their potential use in the development of oncology products.
关键词：tetrahydronaphthalene;hexahydroisoquinoline;hexahydrocinnoline;antitumor activity