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标题：Synthesis,anti-inflammatory,analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles
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作者：ADEL H. MANDOUR ; ESLAM R. EL-SAWY ; KAMEL H. SHAKER 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2010
卷号：60
期号：1
页码：73-88
DOI：10.2478/v10007-010-0009-8
语种：English
出版社：Sciendo
摘要：A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a–j,5a–j and 6a–j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities.Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carboxaldehydes 1a–j,2a–j and 3a–j with ten times their mass of polyphosphoric acid as a condensing agent.The newly synthesized compounds were evaluated for their anti-inflammatory,analgesic and anticonvulsant activities compared to indomethacin,flufenamic acid and diazepam as positive controls.Detailed synthesis,spectroscopic and toxicity data are reported.
关键词：indole-3-carboxaldehyde;anti-inflammatory activity;anticonvulsant activity;analgesic activity