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标题：Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity
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作者：NADEEM SIDDIQUI ; ARPANA RANA ; SUROOR A. KHAN 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2009
卷号：59
期号：4
页码：441-451
DOI：10.2478/v10007-009-0031-x
语种：English
出版社：Sciendo
摘要：Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'- -(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones.Structures of all the compounds were confirmed on the basis of spectral and elemental analyses.All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium.Interestingly,all the compounds showed protections against seizures in the range 50–100 % indicative of the promising nature of the compounds against seizure spread.Compounds 5b and 5c showed complete protection against MES induced seizures.
关键词：benzothiazole;thiadiazole;anticonvulsant;neurotoxicity;hepatotoxicity