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标题：Synthesis,anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines
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作者：SUBHAS S. KARKI ; RAHUL HAZARE ; SUJEET KUMAR 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2009
卷号：59
期号：4
页码：431-440
DOI：10.2478/v10007-009-0040-9
语种：English
出版社：Sciendo
摘要：Various 6-aralkyl-9-substituted-6H-indolo[2,3-b]quinoxalines were synthesized by reaction of 1,5-disubstituted 2,3-dioxo-2,3-dihydroindole and orthophenylene diamine.Appreciable anticancer activity of compounds 5b,5d,5g and 5l at various cell lines among 59 human tumor cell panels was observed.All the synthesized compounds were evaluated for cytostatic activity against human Molt 4/C8 and CEM T-lymphocytes as well as for murine L1210 leukemia cells.Compound 5h exhibited an IC50 of 23 mmol L–1 against Molt 4/C8 and 38 mmol L–1 against CEM compared to melphalan 3.2 mmol L–1 and 2.5 mmol L–1,respectively.The IC50 for compound 7i against L1210 was 7.2 mmol L–1 compared to melphalan 2.1 mmol L–1.
关键词：indolo[2;3-b]quinoxaline;cytostatic activity;anticancer activity