文章基本信息

标题：Development of a radiolabeled -human chorionic gonadotropin
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作者：AMIR R. JALILIAN ; MOHAMMAD REZA KHOSHDEL ; JAVAD GAROUSI 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2009
卷号：59
期号：4
页码：421-429
DOI：10.2478/v10007-009-0035-6
语种：English
出版社：Sciendo
摘要：b-Human chorionic gonadotropin (b-hCG) was successively labeled with [67Ga]-gallium chloride after conjugation with freshly prepared diethylenetriaminepentaacetic acid dianhydride (ccDTPA).After solid phase purification of the radiolabeled hormone,high performance liquid chromatography showed radiochemical purity higher than 95 % under optimized conditions (specific activity = 22–23 TBq mM–1,labeling efficiency 80 %).Preliminary in vivo studies (ID g–1,%) in male wild-type rats showed marked gonadal uptake of the tracer after 240 minutes in agreement with the biodistribution studies and reported b-hCG receptors.Target to blood ratios were 5.1 and 15.2 after 3 and 24 hours,respectively,while target to muscle ratios were 35 and 40 after 3 and 24 hours,respectively.
关键词：b-hCG;radiolabeling;biodistribution;radiopharmaceutical