文章基本信息

标题：Metalloantibiotics: Synthesis,characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori
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作者：ANWAR R. SHAIKH ; RAJANI GIRIDHAR ; FRANCIS MEGRAUD 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2009
卷号：59
期号：3
页码：259-271
DOI：10.2478/v10007-009-0027-6
语种：English
出版社：Sciendo
摘要：Novel organometallic compounds have been prepared by complexing the fluoroquinolones,norfloxacin,ofloxacin,ciprofloxacin,sparfloxacin,lomefloxacin,pefloxacin and gatifloxacin,with bismuth.The complexes were characterized by UV,IR,atomic absorption spectroscopy,elemental analysis,differential scanning calorimetry,thermogravimetric analysis and mass spectrometry.Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated.These compounds were found to possess strong activity against Helicobacter pylori with a minimum inhibitory concentration of 0.5 mg L–l.They also exhibited moderate activity against Escherichia coli,Staphylococcus aureus,Bacillus pumilus and Staphylococcus epidermidis.These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H.pylori related ailments.
关键词：fluoroquinolone;bismuth;complex;antimicrobial activity;Helicobacter pylori