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标题：Synthesis of certain pyrrole derivatives as antimicro-bial agents
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作者：MOSAAD SAYED MOHAMED ; RAMDAN AHMED EL-DOMANY ; RANIA HELMY ABD EL-HAMEED 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2009
卷号：59
期号：2
页码：145-158
DOI：10.2478/v10007-009-0016-9
语种：English
出版社：Sciendo
摘要：In an effort to establish new pyrroles and pyrrolo[2,3-d] pyrimidines with improved antimicrobial activity we report here the synthesis and in vitro microbiological evaluation of a series of pyrrole derivatives.A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin,primary aromatic amines and malononitrile,from which a number of pyrrole derivatives (2a-d to 5a-d) and pyrrolo[2,3-d]pyrimidines (6a-d to 10a,d) were synthesized.The in vitro antimicrobial testing of the synthesized compounds was carried out against Gram-positive,Gram-negative bacteria and fungi.Some of the prepared compounds,[2-amino-1-(2-methylphenyl)- -4,5-diphenyl-1H-pyrrole-3-carbonitriles (1b),2-amino-3- -carbamoyl-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrroles (2b),N-(3-cyano-1-(2-methylphenyl)-4,5-diphenyl-1H- -pyrrol-2-yl)-acetamides (3b),N-(3-cyano-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamides (3c),2-amino-1-(4-methoxyphenyl)-4,5-diphenyl-3-tetrazolo-1H-pyrroles (5d),7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo [2,3-d]pyrimidin-4(3H)-ones (7d),7-(3-methylphenyl)-5,6- -diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-thione (9b) and N-(7-(2-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d] pyrimidine)-N-aryl amines (10a)] showed potent antimicrobial activity.
关键词：pyrrole;pyrrolopyrimidine;antimicrobial activity