文章基本信息

标题：Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals
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作者：AMANY HASSAN M. El SHAZLY ; ATEF MOHAMED MAHMOUD ; NEVINE SALAH DARWISH 等
期刊名称：Acta Pharmaceutica
电子版ISSN：1846-9558
出版年度：2009
卷号：59
期号：1
页码：67-73
DOI：10.2478/v10007-009-0009-8
语种：English
出版社：Sciendo
摘要：This study sought to determine the potential prophylactic and antioxidant effects of aminoguanidine in experimentally induced diabetes.Four groups of Wistar rats,each composed of ten rats,were used.Two groups served as control.In group 3,diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg kg–1).In group 4,diabetes was induced and treated with aminoguanidine (100 mg kg–1 daily) orally for 3 months.Levels of serum glucose,glutathione peroxidase,glutathione reductase and erythrocytes catalase were analyzed on day 90 of the experiment.Retinal and kidney specimens were examined histopathologically after sacrifice of the animals.A significant antioxidant effect of aminoguanidine and its prophylactic role in diabetic retinopathy and nephropathy were observed in experimental animals.
关键词：aminoguanidine;diabetic retinopathy;nephropathy;nitric oxide;glycated end product;antioxidants