文章基本信息

标题：EFFECTS OF EXERCISE AT HIGH ALTITUDE ON MICRONUCLEUS FREQUENCY
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作者：Akpınar Nee ; Hamurcu Zuhal ; Donmez-Altuntas Hamiyet 等
期刊名称：Ovidius University Annals, Series Physical Education and Sport/Science, Movement and Health
印刷版ISSN：1224-7359
出版年度：2010
卷号：10
期号：2
页码：330-332
语种：English
出版社：Ovidius University Press
摘要：Objective: The aim of this work is to study effects of acute hypoxia on micronucleus frequency during exercise.Research methods and subjects: Study group was formed with students of Erciyes University Vocational School of Physical Education and Sports.Students were within similar age and fitness range,mean age 23.35 ± 1.66 year,mean height 168.20 ± 7.32 cm,mean body mass 60.05 ± 8.76 kg,body mass index 21.12 ± 2.17 kg/m2,10 female and 10 male totally 20 students were included in the study.All students were stayed at Mount Erciyes (2200-2500m) and exercised ski,3 hours a day for 5 days.1st day and 5th day oxygen saturation,systolic and diastolic blood pressures,heart rate were measured and blood samples were collected.In order to analyze heart rate,systolic and diastolic blood pressures,oxygen saturation between male and female groups Independent Sample Test was used.Paired sample test was used to compare 1st and 5 th day data.Linear regression analyses were used to analyze micronucleus frequency between male and female students.Results: In the first day and fifth day no significantly difference was observed before and after exercise in micronucleus frequency (p>0.,05).However after 5 days exercise at high altitude,micronucleus frequencies when compared to 1st day pre and post exercise micronucleus frequencies showed very significant increase (p<0.001).In the first day no statistically significant difference was observed before and after exercise in systolic and diastolic blood pressures between male and female groups (p>0.05),oxygen saturation decreased after exercise,heart rate increased after exercise (p<0.,05).In the fifth day between male and female groups systolic and diastolic blood pressures,heart rate and oxygen saturation showed no significant difference compared to 1st day (p > 0.05),after exercise in female group in 5th day systolic blood pressure and oxygen saturation increased compared to 1st day post exercise period (p<0.05),in male group 5th day systolic blood pressures and heart rate increased compared to 1st day post exercise period (p<0.05).Discussion and conclusion: Results of our study clearly shows that high altitude causes DNA damage and may have mutagenic effects.
关键词：High altitude;hypoxia;DNA damage;micronucleus.