文章基本信息

标题：Administration of Extract of Mango’s Mistletoes on Liver Histology of Codein-Induced Rats
其他标题：Pemberian Ekstrak Benalu Mangga terhadap Perubahan Histologis Hepar Tikus yang Diinduksi Kodein
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作者：Sekar Maya Wijaya M ; Sekar Maya Wijaya M ; Lisdiana 等
期刊名称：Biosaintifika: Journal of Biology & Biology Education
印刷版ISSN：2085-191X
电子版ISSN：2338-7610
出版年度：2014
卷号：6
期号：2
页码：80-86
DOI：10.15294/biosaintifika.v6i2.3103
语种：English
出版社：Universitas Negeri Semarang
摘要：Mango’s mistletoes contain quercetin, a hepatoprotector. Codein is a type of alkaloids widely used as drug. Codein overdose can damage the liver. This study aims to inventigate the effect of the administration of extract of mango’s mistletoes on the changes of liver histology of codein-induced rats. As many as 20 male wistar rats were divided into 5 groups (K0, K, KB1, KB2, and KB3). K0 group were given only standard diet and water daily. K group were given codeine at 12mg/rats for 7 days, and afterwards they were given only standard diet and water daily. KB1 group were given codeine at 12mg/rats for 7 days and then were given extract of mango’s mistletoes at 22 mg/rats until day 21, KB2 group were given codeine at 12mg/rats for 7 days and then were given extract of mango’s mistletoes at 44 mg/rats until day 21, and KB3 group were given codeine at 12mg/rats for 7 days and were given extract of mango’s mistletoes at 88 mg/rats until day 21. On day 27, all rats were killed, the livers were taken out for preparations with HE staining for histology examination. Research showed that K0 group was significantly different (p <0.05) to K, KB1, KB2, and KB3 groups, whereas K group was not significantly different to KB1, KB2 and KB3 groups. Rats in K group showed the changes in histological appearance such as periportal inflammation and degeneration, whereas rats in KB1, KB2, KB3 groups showed similar histological appearance but with necrosis.
其他摘要：Benalu mangga mengandung senyawa kuersetin yang bertindak sebagai hepatoprotektor. Kodein merupakan jenis alkaloid dan banyak digunakan sebagai obat. Oversdosis kodein dapat menyebabkan kerusakan hepar. Penelitian ini bertujuan untuk mengetahui pengaruh p
关键词：Extract of Mango’s Mistletoes; Liver Histology