文章基本信息

标题：Glutathione Antioxidant Status of Pulmonary Tuberculosis Patients in The Lung Health Center (Bkpm) Makassar
其他标题：Status Antioksidan Glutation pada Pasien Tuberkulosis Paru di Balai Kesehatan Paru (Bkpm) Makassar
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作者：Ari Yuniastuti ; Ari Yuniastuti ; Irawan Yusuf 等
期刊名称：Biosaintifika: Journal of Biology & Biology Education
印刷版ISSN：2085-191X
电子版ISSN：2338-7610
出版年度：2014
卷号：5
期号：2
页码：74-81
DOI：10.15294/biosaintifika.v5i2.2745
语种：English
出版社：Universitas Negeri Semarang
摘要：Antioxidants prevent hosts against free radicals. In pulmonary tuberculosis (TB) patients, the low level of antioxidants may cause tissue damage in oxidative hosts. One of antioxidants is glutathione. The poor glutathione level correlates with immune system disorder. The current study aimed to determine glutathione plasma levels in pulmonary tuberculosis patients. The study design was prospective cohort. Pulmonary TB samples were obtained from patients in the Lung Health Centre (BBKPM) in Makassar, and they were selected based on the inclusive and exclusive criteria and on their admittance times (a consecutive sampling technique). Two mililiters of blood was taken from each sample and the glutathione level was examined using ELISA. The study indicated that the glutathione level of the pulmonary TB patients before administered with antitubeculosis drug was 0.48383±0.0344 mM and after antituberculosis drug was 0.49465±0.0371 mM. After administration of antituberculosis drug the glutathione level increased by 2.2%, although still lower than normal glutathione level.
其他摘要：Antioksidan merupakan senyawa untuk pertahanan tubuh host terhadap radikal bebas. Pada pasien tuberkulosis paru (TB paru), rendahnya antioksidan menyebabkan kerusakan jaringan. Salah satu antioksidan tubuh adalah glutation. Rendahnya glutation berhubungan
关键词：Pulmonary tuberculosis; glutamate cystein ligase; glutathione