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  • 标题:Spectrophotometric determination of ceftriaxone using 4-dimethylaminobenzaldehyde
  • 本地全文:下载
  • 作者:F.M.A. Rind ; M.G.H. Laghari ; A.H. Memon
  • 期刊名称:Pakistan Journal of Analytical & Environmental Chemistry
  • 印刷版ISSN:1996-918X
  • 电子版ISSN:2221-5255
  • 出版年度:2008
  • 卷号:9
  • 期号:1
  • 页码:1-7
  • 语种:English
  • 出版社:National Centre of Excellence in Analytical Chemsitry
  • 摘要:A new spectrophotometric method has been developed for the determination of the potent antibiotic ceftriaxone (CF) by derivatization with 4-dimethylaminobenzaldehyde (DAB). The derivative indicated molar absorptivity of 5.3 x 10 3 L mol -1 cm -1 at Îmax 397 nm and obeyed the Beerís law within 20-100 µgmL -1 . The color reaction was highly stable and did not show any change in absorbance up to 24 h. The method was successfully applied for the determination of CF from various pharmaceutical preparations available in local market. The amounts of CF found in various pharmaceutical preparations were within 237.4-990 mg ampoule -1 with standard deviation (SD) ± 0.0004-0.044 (n=3) respectively..
  • 关键词:Ceftriaxone;4-dimethylaminobenzaldehyde;spectrophotometry
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