文章基本信息

标题：Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes
本地全文：下载
作者：Young Keul Jeon ; Jae Boum Youm ; Kotdaji Ha 等
期刊名称：Advances in Physiology Education
印刷版ISSN：1043-4046
电子版ISSN：1522-1229
出版年度：2020
卷号：44
期号：3
页码：323-333
DOI：10.1152/advan.00093.2019
出版社：The American Physiological Society
摘要：To understand the excitation-contraction (E-C) coupling of cardiomyocytes, including the electrophysiological mechanism of their characteristically long action potential duration, is one of the major learning goals in medical physiology. However, the integrative interpretation of the responses occurring during the contraction-relaxation cycle is challenging due to the dynamic interaction of underlying factors. Starting in 2017, we adopted the mathematical computer simulation model of human ventricular myocyte (Cardiac E-C_Sim), hypothesizing that this educational technology may facilitate students’ learning of cardiac physiology. Here, we describe the overall process for the educational application of Cardiac E-C_Sim in the human physiology practicum of Seoul National University College of Medicine. We also report the results from questionnaires covering detailed assessment of the practicum class. The analysis of results and feedback opinions enabled us to understand how the students had approached the problem-solving process. As a whole, the students could better accomplish the learning goals using Cardiac E-C_Sim, followed by constructive discussions on the complex and dynamic mechanisms of cardiac E-C coupling. We suggest that the combined approach of lecture-based teaching and computer simulations guided by a manual containing clinical context would be broadly applicable in physiology education.
关键词：cardiac physiology; excitation-contraction coupling; mathematical simulation; practicum; virtual experiment