文章基本信息

标题：Syntheses of C2′-Fluorinated Analogs of Solamin
本地全文：下载
作者：Naoto Kojima ; Hiromi Hayashi ; Hiroki Iwasaki 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：7
页码：675-678
DOI：10.1248/cpb.c20-00223
出版社：The Pharmaceutical Society of Japan
摘要：The details of the total syntheses of C2′-fluorinated analogs of solamin, an antitumor annonaceous acetogenin, are described. Fluorine was enantioselectively introduced at the C2′-position by organocatalytic α-fluorination of the aldehyde according to a previously reported method. C2′-fluorinated solamin and its C2′-diastereomer were synthesized by the Sonogashira coupling of a tetrahydrofuran fragment and fluorine-containing γ-lactone fragments.
关键词：annonaceous acetogenin;fluorinated analog;antitumor agent;convergent synthesis