文章基本信息

标题：Long QT syndrome - causes and risk factors
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作者：Erwin Ciechański ; Magda Ciechańska ; Krystian Ciechański 等
期刊名称：Journal of Education, Health and Sport
电子版ISSN：2391-8306
出版年度：2018
卷号：8
期号：10
页码：111-116
DOI：10.5281/zenodo.1461597
语种：English
出版社：Kazimierz Wielki University
摘要：Sudden cardiac death is a major public health challenge, which can be caused by genetic or acquired structural or electrophysiological abnormalities. These abnormalities include channelopathies such as long QT, short QT and Brugada syndromes. Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes (TdP). Main causes of acquired syndrome are specific medications and/or electrolytes imbalance. On the other hand common congenital causes are Jervell and Lange-Nielsen or Romano- Ward syndromes. Patients with risk factors, treated with specified QT prolongating drugs always require slow dose titration and electrocardiography monitoring. Aim of this study is to comprehensively and critically review the pathomechanisms of QT prolongation, risk factors and prevention methods.
关键词：Sudden cardiac death is a major public health challenge, which can be caused by genetic or acquired structural or electrophysiological abnormalities. These abnormalities include channelopathies such as long QT, short QT and Brugada syndromes. Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes (TdP). Main causes of acquired syndrome are specific medications and/or electrolytes imbalance. On the other hand common congenital causes are Jervell and Lange-Nielsen or Romano- Ward syndromes. Patients with risk factors, treated with specified QT prolongating drugs always require slow dose titration and electrocardiography monitoring. Aim of this study is to comprehensively and critically review the pathomechanisms of QT prolongation, risk factors and prevention methods.