文章基本信息

标题：Prolactin – friendly lactation hormone or hostile cancerogenic factor?
本地全文：下载
作者：Milena Leziak ; Sylwiusz Niedobylski ; Klaudia Żak 等
期刊名称：Journal of Education, Health and Sport
电子版ISSN：2391-8306
出版年度：2019
卷号：9
期号：9
页码：247-252
DOI：10.5281/zenodo.3401873
语种：English
出版社：Kazimierz Wielki University
摘要：Prolactin is a hormone secreted by lactotrophic cells of the pituitary gland and its main function is stimulating lactation. Binding prolactin by its membrane receptor leads to the activation of signalling pathway that enables cell proliferation and differentiation. Due to this mechanism, the potential oncogenic role of the hormone is of great interest. Prolactin and its receptor have many forms and a complicated signalling pathway, that is why defining prolactin’s specific role in cancerogenesis is difficult and poses a serious challenge. Researches also indicate an important role of extra-pituitary prolactin synthesised in many other tissues in the process of cancerogenesis. This article focuses on connection between prolactin and breast cancer, as it is the most common cancer in women. In several studies, prolactin and its receptor were significantly associated with an increased breast cancer risk. Recent research papers focus also on the treatment of breast cancer, using knowledge about prolactin and its role in the development of the tumour.
关键词：Prolactin is a hormone secreted by lactotrophic cells of the pituitary gland and its main function is stimulating lactation. Binding prolactin by its membrane receptor leads to the activation of signalling pathway that enables cell proliferation and differentiation. Due to this mechanism, the potential oncogenic role of the hormone is of great interest. Prolactin and its receptor have many forms and a complicated signalling pathway, that is why defining prolactin’s specific role in cancerogenesis is difficult and poses a serious challenge. Researches also indicate an important role of extra-pituitary prolactin synthesised in many other tissues in the process of cancerogenesis. This article focuses on connection between prolactin and breast cancer, as it is the most common cancer in women. In several studies, prolactin and its receptor were significantly associated with an increased breast cancer risk. Recent research papers focus also on the treatment of breast cancer, using knowledge about prolactin and its role in the development of the tumour.