文章基本信息

标题：AGRANULOCYTOSIS AND CARDIAC TOXICITY - SERIOUS SIDE EFFECTS OF CLOZAPINE
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作者：Ewa Krzewicka-Romaniuk ; Dagna Siedlecka ; Artur Romaniuk 等
期刊名称：Journal of Education, Health and Sport
电子版ISSN：2391-8306
出版年度：2019
卷号：9
期号：9
页码：1182-1186
DOI：10.5281/zenodo.3464948
语种：English
出版社：Kazimierz Wielki University
摘要：Clozapine is probably the most effective antipsychotic. Treatment with clozapine is proved to decrease frequency of suicidal behavior. It is related to decrease in use of psychoactive substances and decrease in frequency and intensity of aggressive behavior among patients. It decreases the risk of rehospitalization and relapse. However because of serious, potentially fatal side effects like agranulocytosis or cardiac toxicity, use of clozapine is limited to schizophrenia symptoms partially or fully resistant to treatment with other antipsychotic drugs, or accompanied by persistent suicidal or self-injurious behavior.
关键词：Clozapine is probably the most effective antipsychotic. Treatment with clozapine is proved to decrease frequency of suicidal behavior. It is related to decrease in use of psychoactive substances and decrease in frequency and intensity of aggressive behavior among patients. It decreases the risk of rehospitalization and relapse. However because of serious, potentially fatal side effects like agranulocytosis or cardiac toxicity, use of clozapine is limited to schizophrenia symptoms partially or fully resistant to treatment with other antipsychotic drugs, or accompanied by persistent suicidal or self-injurious behavior.