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标题：The impact of artificial sweeteners on the risk and course of large intestinal adenocarcinoma in the elderly
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作者：Martyna Goljat ; Paweł Niewiadomski ; Maciej Lazarek 等
期刊名称：Journal of Education, Health and Sport
电子版ISSN：2391-8306
出版年度：2019
卷号：9
期号：9
页码：992-1008
DOI：10.5281/zenodo.3462971
语种：English
出版社：Kazimierz Wielki University
摘要：Background: There are many confirmed risk factors for development of the colorectal cancer, which is one of the most common malignant tumor among both females and males. Moreover, it is a cause of significant percentage of all cancer-related deaths. Even with treatment, the 5-year survival rate is very low. We concentrate on impact of artificial sweeteners on risk and course of adenocarcinoma of colon. Results: In recent years, consumption of low-calorie and calorie-free sweeteners (LCS) has increased. It may be caused by campaigns promoting obesity fighting, low calorie drinks, diets, as well as by increase of social awareness regarding negative health associations associated with high sugar consumption. We can divide LCS into two main groups: semi-synthetic and synthetic sweeteners. Substances from the first group are homogeneous, however those from the second group have different physical and chemical properties, due to different structure. LCS quickly gained a lot of interest and scientists are still questioning their safety, especially during prolonged use. Many studies have shown no link between LCS and carcinogenesis, however there are few studies concerning artificial sweeteners and colon cancer connection. Discussion: It is important to remember that there are many dietary habits that are connected to development of colorectal adenocarcinoma. It is difficult to assess the effect of sweeteners separately. Conclusions: The potential connection between LCS and development of colorectal cancer is not fully examined. Further studies of this correlation should be conducted.
关键词：Background: There are many confirmed risk factors for development of the colorectal cancer, which is one of the most common malignant tumor among both females and males. Moreover, it is a cause of significant percentage of all cancer-related deaths. Even with treatment, the 5-year survival rate is very low. We concentrate on impact of artificial sweeteners on risk and course of adenocarcinoma of colon. Results: In recent years, consumption of low-calorie and calorie-free sweeteners (LCS) has increased. It may be caused by campaigns promoting obesity fighting, low calorie drinks, diets, as well as by increase of social awareness regarding negative health associations associated with high sugar consumption. We can divide LCS into two main groups: semi-synthetic and synthetic sweeteners. Substances from the first group are homogeneous, however those from the second group have different physical and chemical properties, due to different structure. LCS quickly gained a lot of interest and scientists are still questioning their safety, especially during prolonged use. Many studies have shown no link between LCS and carcinogenesis, however there are few studies concerning artificial sweeteners and colon cancer connection. Discussion: It is important to remember that there are many dietary habits that are connected to development of colorectal adenocarcinoma. It is difficult to assess the effect of sweeteners separately. Conclusions: The potential connection between LCS and development of colorectal cancer is not fully examined. Further studies of this correlation should be conducted.