摘要:Background. We conduct a systematic study of the effect of balneotherapy spa Truskavets (Ukraine) on blood pressure. The aim of this study is to elucidate the links between normal and marginal blood pressure, on the one hand, and some neural, endocrine, metabolic and biophysical factors on the other. Material and research methods. We recorded twice at ten women and ten men aged 33-76 years without clinical diagnose Blood Pressure, Heart Rate, heart rate variability (HRV), electroencephalogram (EEG), electro-skin conductance acupuncture points (ESCAP) Pg(ND), TR(X) and MC(AVL), determined the rate of electronegative nuclei of buccal epithelium (named as Electrokinetic Index) as well as plasma levels of Calcitonin, Testosterone, Cortisol, Triiod-thyronin, Cholesterol, Uric Acid, Chloride, Phosphate, Sodium, Potassium, Calcium and Magnesium. Results. Observed contingent characterized generally normal for a particular age or borderline high blood pressure, predominantly diastolic. In the final regression model were included 4 metabolic parameters (Cholesterol, Uric Acid, Phosphate and Calcium), 3 neural (α-rhythm Index as well as RMSSD and Triangulary Index as markers of Vagal tone) and ESCAP TR(X) Right as marker activity of endocrine system, which taken together determines Systolic Blood Pressure on 77%. Diastolic Blood Pressure determined on 74% by 7 neural parameters (4 HRV markers of Vagal and Sympathetic tone as well as α-rhythm Amplitude and Deviation and θ-rhythm Frequency), 2 biophysic parameters (ESCAP TR(X) Right and Electrokinetic Index as marker of biological age) as well as Chloride and Hender. Conclusion. Normal and marginal blood pressure determined by some neural, biophysical and metabolic factorss well as Hender.