文章基本信息

标题：Vancomycin Dosage and Its Association with Clinical Outcomes in Pediatric Patients with Gram-Positive Bacterial Infections
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作者：Sooyoung Shin ; Hyun Joo Jung ; Sang-Min Jeon 等
期刊名称：Risk Management and Healthcare Policy
印刷版ISSN：1179-1594
电子版ISSN：1179-1594
出版年度：2020
卷号：13
页码：685-695
DOI：10.2147/RMHP.S244836
出版社：Dove Medical Press Ltd
摘要：Aim: The aim of this study was to evaluate whether vancomycin trough concentrations at initial steady state are associated with clinical and microbiological outcomes along with vancomycin-related nephrotoxicity in pediatric patients with Gram-positive bacterial (GPB) infections. Methods: A retrospective cohort study of pediatric patients who received vancomycin for ≥ 72 hours during 2008– 2016 was conducted. Study patients were divided into three cohorts in accordance with their first trough levels at steady state: 10 mg/L (high-trough; reference) cohorts. Results: Of the 201 patients eligible for study inclusion, 60 patients in the lower- and low-trough cohorts, respectively, were idect 3ntified via propensity score matching and analyzed against 30 high-trough patients in each comparison pair (neonates were excluded due to small sample size). Lower-trough patients were at a greater risk for prolonged therapy, retreatment, and dose adjustment than high-trough patients. Final steady-state troughs remained substantially lower in both the lower- and low-trough cohorts ( p 10 mg/L troughs in pediatric patients with GPB infections.
关键词：pediatrics; vancomycin; drug monitoring; Gram-positive bacterial infection