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标题：Effectiveness of including probiotics to Helicobacter pylori eradication therapies
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作者：Rieko Mukai ; Osamu Handa ; Yosuke Suyama 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2020
卷号：67
期号：1
页码：102-104
DOI：10.3164/jcbn.20-37
出版社：The Society for Free Radical Research Japan
摘要：The eradication rate of Helicobacter pylori ( H. pylori ) with proton pump inhibitors, amoxicillin, and clarithromycin has reportedly decreased. Some studies have found probiotics to be useful in eradicating H. pylori , but these effects have not been sufficiently investigated. We aimed to elucidate the role of probiotics in eradicating H. pylori infection. Patients in our hospital with H. pylori infection that received standard treatment from January 2015 to December 2016 were retrospectively evaluated ( n = 468). They were divided into three groups based on their treatment regime, being either proton pump inhibitors, amoxicillin, or clarithromycin (PPI group), vonoprazan, amoxicillin, or clarithromycin (VPZ group), and proton pump inhibitors, amoxicillin, or clarithromycin/probiotics (Miya-BM ® ) (PPI + MBM group). We retrospectively evaluated the H. pylori eradication rate and reported side effects. According to intention-to-treat analyses, the eradication rate of H. pylori was significantly higher in the PPI + MBM group (87.1%) than in the PPI group (70.1%). There was no difference in side effects between any of the three groups. In conclusion, Miya-BM ® may have an additive effect when included with eradication therapies for H. pylori .
关键词：probiotics;eradication therapy of Helicobacter pylori;Miya-BM®