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标题：Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature
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作者：Li Zhong ; Xue-Zhi Shi ; Lei Su 等
期刊名称：Military Medical Research
印刷版ISSN：2054-9369
出版年度：2020
卷号：7
期号：1
页码：1-6
DOI：10.1186/s40779-020-00253-9
出版社：BioMed Central
摘要：Intracranial infection after craniotomy is one of the most serious postoperative complications, especially multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacterial meningitis, and strongly affects the prognosis of patients. Current treatment experience regarding these infections is scarce. We report a case of severe intracranial infection of XDR Acinetobacter baumannii (A. baumannii) that was treated by intravenous (IV) injection, sequential intraventricular (IVT) injection of tigecycline and polymyxin B, and other anti-infective drugs. Good results were obtained, and the patient was eventually discharged from the hospital. This case is characterized by intracranial infection. The polymyxin B IV + IVT pathway is an ideal treatment strategy for XDR A. baumannii. The tigecycline IVT pathway is also a safe treatment option.
关键词：Intraventricular injection of tigecycline;Polymyxin B;Intracranial infection;Acinetobacter baumannii