文章基本信息

标题：Mitotic chromosome organization: General rules meet species-specific variability
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作者：Tomáš Beseda ; Petr Cápal ; Ivona Kubalová 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2020
卷号：18
页码：1311-1319
DOI：10.1016/j.csbj.2020.01.006
出版社：Computational and Structural Biotechnology Journal
摘要：Research on the formation of mitotic chromosomes from interphase chromatin domains, ongoing for several decades, made significant progress in recent years. It was stimulated by the development of advanced microscopic techniques and implementation of chromatin conformation capture methods that provide new insights into chromosome ultrastructure. This review aims to summarize and compare several models of chromatin fiber folding to form mitotic chromosomes and discusses them in the light of the novel findings. Functional genomics studies in several organisms confirmed condensins and cohesins as the major players in chromosome condensation. Here we compare available data on the role of these proteins across lower and higher eukaryotes and point to differences indicating evolutionary different pathways to shape mitotic chromosomes. Moreover, we discuss a controversial phenomenon of the mitotic chromosome ultrastructure – chromosome cavities – and using our super-resolution microscopy data, we contribute to its elucidation.
关键词：Chromatin fiber folding ; Chromosome cavities ; Chromosome condensation ; Chromosome conformation capture ; Chromosome scaffold ; Structural maintenance of chromosomes proteins