文章基本信息

标题：Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus
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作者：Satoki Aoki ; Takako Aboshi ; Yoshihito Shiono 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2020
卷号：68
期号：5
页码：436-442
DOI：10.1248/cpb.c19-01009
出版社：The Pharmaceutical Society of Japan
摘要：Six new sesquiterpenes, tsukiyols A–C, neoilludin C, and 4- O -methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A–B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A–C, 4- O -methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4- O -methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca 2+ -signal transduction.
关键词：sesquiterpene;Omphalotus japonicus;NMR;mushroom;Saccharomyces cerevisiae