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标题：Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study
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作者：Jesse D. Thacher ; Aslak H. Poulsen ; Nina Roswall 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2020
卷号：128
期号：5
页码：1-9
DOI：10.1289/EHP6273
出版社：OCR Subscription Services Inc
摘要：Background: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. Objectives: We aimed to investigate whether residential road traffic noise increases the risk for hypertension. Methods: In a population-based cohort of 57,053 individuals 50–64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥ 2 prescriptions and ≥ 180 defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models. Results: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals. Conclusion: The present study does not support an association between road traffic noise and filled prescriptions for AHTs.