文章基本信息

标题：Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts
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作者：Qi Wei ; Yishu Zhan ; Bingzhi Chen 等
期刊名称：Food Science & Nutrition
电子版ISSN：2048-7177
出版年度：2020
卷号：8
期号：1
页码：332-339
DOI：10.1002/fsn3.1310
出版社：John Wiley & Sons, Ltd.
摘要：Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3 Fe(CN)6 in vitro. Moreover, the effects of EE and EA on α‐glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of α‐glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose‐lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.
关键词：Agaricus blazei Murill;antidiabetic activity;antioxidant activity;HepG2 cells;α‐glucosidase