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标题：Complete genome sequence of Treponema pallidum strain DAL-1
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作者：Marie Zobaníková ; Pavol Mikolka ; Darina Čejková 等
期刊名称：Environmental Microbiome
印刷版ISSN：2524-6372
出版年度：2012
卷号：7
期号：1
页码：12-21
DOI：10.4056/sigs.2615838
摘要：Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
关键词：Spirochaetaceae;Treponema pallidum;syphilis