文章基本信息

标题：What do patients value as incentives for participation in clinical trials? A pilot discrete choice experiment
本地全文：下载
作者：Akke Vellinga Colum Devine Min Yun Ho Colin Clarke
期刊名称：Research Ethics
印刷版ISSN：1747-0161
电子版ISSN：2047-6094
出版年度：2020
卷号：16
期号：1-2
页码：1-13
DOI：10.1177/1747016119898669
出版社：SAGE Publications
摘要：Incentivising has shown to improve participation in clinical trials. However, ethical concerns suggest that incentives may be coercive, obscure trial risks and encourage individuals to enrol in clinical trials for the wrong reasons. The aim of our study was to develop and pilot a discrete choice experiment (DCE) to explore and identify preferences for incentives. A DCE was designed by including following attributes (and levels) of incentives: value, method, and time involvement. To account for trial benefit and risk, each was included as an attribute with levels low, medium and high. For testing purposes, the DCE was administrated using SurveyMonkey in a population of third level students. A total of 245 students, representative of the general student population, participated in the online DCE. The results provide a template to assess and explore the use of different incentive methods in clinical trials. The template can be used in its current format or adapted to particular scenarios. This pilot study provides a feasible methodology to explore the use of incentives for participation in clinical trials and can be adapted to specific trial requirements to provide information for ethical applications or identify the most favourable incentive for participation in clinical trials.
关键词：Randomised controlled trial ; incentive ; discrete choice experiment